Check breakdown pathway of 235 drugs from website and enter in excel
€30-250 EUR
Оплачується при отриманні
I am looking for someone with either medical, biological or pharmacological education to check a list of 235 drugs on the website [login to view URL] and to enter the primary pathway of breakdown in an excel.
The primary (most important) breakdown pathway is always one of 7 different enzymes (CYP2D6, 2C9, 2C19, 3A4, 3A5, 2E1, 1A2) and he correct one needs to be selected in an excel file.
In addition, whether or not the drug is a prodrug (a drug that needs to be modified by an enzyme before showing its effect) needs to be noted.
Hint: allways ignore information about 2D6 and 2C19 ultrarapid and rapid metabolizers... We are not interested in this information.
Example:
The drug amitriptyline
Link: https://www.pharmgkb.org/drug/PA448385#tabview=tab0&subtab=31
Question: What is the primary route of breakdown? (CYP2D6, 2C9, 2C19, 3A4, 3A5, 2E1, 1A2)
Text that contains answer:
Summary
The CPIC Dosing Guideline for amitriptyline recommends an alternative drug for CYP2D6 or CYP2C19 ultrarapid metabolizers and for CYP2D6 poor metabolizers. Consider a 50% dose reduction for CYP2C19 poor metabolizers and a 25% dose reduction for CYP2D6 intermediate metabolizers.
Answer:
The main route of breakdown (ognoring the ultra rapid metabolizer info) is CYP2D6
Question 2: is it a Prodrug?
Text that contains the answer:
Biotransformation
Exclusively hepatic, with first pass effect. Amitriptyline is demethylated in the liver to its primary active metabolite, nortriptyline.
answer:
Yes, it is a prodrug.
The aim is to make a list of drugs with the primary breakdown enzymes. I will then use this list to see which drugs are not broken down correctly if one of these enzymes is defective.
You need to have some background in this field to bid. I will also award to 2 independent bidders and compare the results, so accurate work is required.
I am attaching a sample of the to do list to this project.
Milestones will be uploaded in full, payment after completion.
ID Проекту: #5281827
Про проект
Доручено:
hello, i am a medical student i have the necessary background to do this project; please contact me; thank you and have a nice day
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